Insulin resistance (IR) is the major feature of metabolic syndrome, including type 2 diabetes.
IR studies are mainly focused on peripheral tissues, such as muscle and liver. There is …

The objective was to determine whether stress‐activated protein kinases (SAPKs) mediated
the transfer of diabetes‐induced stress signals from the periphery to somata of sensory …

Diabetic polyneuropathy (DPN) shows more severe functional and structural changes in
type 1 than in type 2 human and experimental diabetes. We have previously suggested that …

Dorsal root ganglia neurons in culture die through programmed cell death when exposed to
elevated glucose, providing an in vitro model system for the investigation of the mechanisms …

Dorsal root ganglia (DRG) neurons degenerate in diabetic neuropathy (DN) and exhibit
mitochondrial damage. We studied mitochondria of cultured DRG neurons exposed to high …

Diabetic neuropathies (DNs) differ in clinical course, distribution, fiber involvement (type and
size), and pathophysiology, the most typical type being a length-dependent distal symmetric …

Hyperglycemia-induced mitochondrial dysfunction contributes to sensory neuron pathology
in diabetic neuropathy. Although Schwann cells (SCs) also undergo substantial …

Diabetic neuropathy develops on a background of hyperglycemia and an entangled
metabolic imbalance. There is increasing evidence of central nervous system involvement in …

Drastic increase in diabetic patients poses serious problems in the care of neuropathy so
that there needs to explore the pathogenesis and to establish the effective treatment. Recent …

In patients with diabetes, nerve injury is a common complication that leads to chronic pain,
numbness and substantial loss of quality of life. Good glycemic control can decrease the …