Diabetic polyneuropathy (DPN) is the most frequent and prevalent chronic complication of
diabetes mellitus (DM). The state of persistent hyperglycemia leads to an increase in the …

We explored the specific impact of polyol pathway hyperactivity on dorsal root ganglia
(DRG) using transgenic mice that overexpress human aldose reductase because DRG …

Diabetic neuropathy (DN) is one of the main microvascular complications of both type 1 and
type 2 diabetes mellitus. Sometimes, this could already be present at the time of diagnosis …

Glucose-mediated oxidative stress and alterations in cyclooxygenase (COX) pathway
activity with secondary deficits of endoneurial perfusion have been implicated in the …

Recent evidence indicates that Parkinson's disease and diabetes, both age-related chronic
diseases, share remarkably similar dysregulated pathways. Exposure to environmental …

Multiple avenues of research including epidemiology, molecular genetics and cell biology
have identified links between Parkinson's disease and type 2 diabetes mellitus. Several …

Spinal cord neurons located in laminae I–III respond to nociceptive stimuli and participate in
the transmission of painful information to the brain. In the present study we evaluated if …

This study evaluated poly (ADP-ribose) polymerase (PARP) inhibition as a new therapeutic
approach for peripheral diabetic neuropathy using clinically relevant animal model and …

Diabetic polyneuropathy (DPN) is a common but intractable degenerative disorder of
peripheral neurons. DPN first results in retraction and loss of sensory terminals in target …

Diabetic peripheral neuropathy (DPN) is a major complication of diabetes mellitus with a
high incidence. Oxidative stress, which is a crucial pathophysiological pathway of DPN, has …