Induction of meiotic maturation in mouse oocytes by adenosine analogs

SM Downs, J Chen - Molecular reproduction and development, 2006 - Wiley Online Library
In this study we have examined the meiosis‐inducing influence of adenosine analogs in
mouse oocytes. When a varied group of nucleosides and nucleotides were tested on …

Gonadotropins, serum, and amino acids alter nuclear maturation, cumulus expansion, and oocyte morphology in hamster cumulus-oocyte complexes in vitro

S Kito, BD Bavister - Biology of reproduction, 1997 - academic.oup.com
Glucose, lactate, and pyruvate (the substrate triad), gonadotropins, serum, and amino acids
were tested on maturation of cumulus-oocyte complexes (COCs) using a simple defined …

Differential regulation of oocyte maturation and cumulus expansion in the mouse oocyte–cumulus cell complex by site-selective analogs of cyclic adenosine …

SM Downs, M Hunzicker-Dunn - Developmental Biology, 1995 - Elsevier
In the present study, we have examined how differential distribution of cyclic adenosine 5′-
monophosphate (cAMP)-dependent protein kinase isozymes within the mouse oocyte …

Chemical signals that regulate mammalian oocyte maturation

JJ Eppig, SM Downs - Biology of Reproduction, 1984 - academic.oup.com
The nature and functions of the chemical signals involved in the acquisition of competence
to resume meiosis, and the maintenance of meiotic arrest in antral follicles are the subjects …

Regulation of oocyte maturation in the mouse: possible roles of intercellular communication, cAMP, and testosterone

RM Schultz, RR Montgomery, PF Ward-Bailey… - Developmental …, 1983 - Elsevier
Experiments were performed to determine if elevation of cumulus cell cAMP results in an
increase in mouse oocyte cAMP while the heterologous gap junctions were intact. Both …

Cumulus cells of oocyte‐cumulus complexes secrete a meiosis‐activating substance when stimulated with FSH

AG Byskov, CY Andersen, A Hossaini… - Molecular …, 1997 - Wiley Online Library
The effect of the different follicular cell types on resumption of meiosis was studied during
stimulation with FSH. Cumulus enclosed oocytes (CEO), denuded oocytes (DO), and …

Regulation of oocyte maturation: communication in the rat cumulus-oocyte complex

I Sherizly, D Galiani, N Dekel - Human Reproduction, 1988 - academic.oup.com
This study was undertaken to analyse the time relationships between breakdown of
communication in the cumulus-oocyte complex and reinitiation of meiosis in the oocyte. In …

Induction of Precocious Germinal Vesicle Breakdown (GVB) by GVB-lncompetent Mouse Oocytes: Possible Role of Mitogen-Activated Protein Kinases Rather than …

F Chesnel, JJ Eppig - Biology of reproduction, 1995 - academic.oup.com
In contrast to fully grown mouse oocytes, growing oocytes released from their preantral
follicles are not capable of resuming meiosis spontaneously. However, when these denuded …

Mouse oocyte mitogenic activity is developmentally coordinated throughout folliculogenesis and meiotic maturation

RB Gilchrist, LJ Ritter, DT Armstrong - Developmental biology, 2001 - Elsevier
Oocytes secrete soluble factors that regulate the growth and differentiation of follicular cells,
including maintenance of the distinctive cumulus cell phenotype. This study determines …

The in-vitro effects of cAMP and cGMP modulators on inter-cellular dye transfer and gene expression levels in rat cumulus cell–oocyte complexes

KA Campen, ZL Clark, MA Olds, KP McNatty… - Molecular and Cellular …, 2016 - Elsevier
Supplementation of in-vitro maturation medium with reagents that inhibit meiotic resumption
whilst supporting normal function of cumulus cell–oocyte complexes (COC) is challenging …