CUL4B promotes gastric cancer invasion and metastasis-involvement of upregulation of HER2
M Qi, M Jiao, X Li, J Hu, L Wang, Y Zou, M Zhao… - Oncogene, 2018 - nature.com
Abstract Cullin 4B (CUL4B) is a scaffold protein overexpressed in several solid
malignancies. It is known to silence tumor suppressor through post-transcriptional manner …
malignancies. It is known to silence tumor suppressor through post-transcriptional manner …
[HTML][HTML] Cullin 4A (CUL4A), a direct target of miR-9 and miR-137, promotes gastric cancer proliferation and invasion by regulating the Hippo signaling pathway
J Deng, W Lei, X Xiang, L Zhang, J Lei, Y Gong… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Abstract Although Cullin 4A (CUL4A) is mutated or amplified in several human cancer types,
its role in gastric cancer (GC) and the mechanisms underlying its regulation remain largely …
its role in gastric cancer (GC) and the mechanisms underlying its regulation remain largely …
CUL4A promotes cell invasion in gastric cancer by activating the NF-κB signaling pathway
Y Gong, XJ Xiang, M Feng, J Chen… - … : Targets and Therapy, 2017 - Taylor & Francis
Cullin 4A (CUL4A) overexpression has been reported to be involved in the carcinogenesis
and progression of many malignant tumors. However, the role of CUL4A in the progression …
and progression of many malignant tumors. However, the role of CUL4A in the progression …
miR-381 and miR-489 suppress cell proliferation and invasion by targeting CUL4B via the Wnt/β-catenin pathway in gastric cancer
Z Fang, M Zhong, Y Wang, X Yuan… - International …, 2018 - spandidos-publications.com
Accumulating evidence has highlighted the critical role of cullin 4B (CUL4B) in driving
tumourigenesis in several malignancies, including gastric cancer (GC); however, the …
tumourigenesis in several malignancies, including gastric cancer (GC); however, the …
[HTML][HTML] Knockdown of CUL4B inhibits proliferation and promotes apoptosis of colorectal cancer cells through suppressing the Wnt/β-catenin signaling pathway
B Song, H Zhan, Q Bian, J Li - International Journal of Clinical and …, 2015 - ncbi.nlm.nih.gov
Colorectal cancer is one of the leading causes of cancer related deaths worldwide. Cullin 4B
(CUL4B) is over-expressed in diverse cancer types. However, the function and precise …
(CUL4B) is over-expressed in diverse cancer types. However, the function and precise …
[HTML][HTML] Knockdown of CUL4B suppresses the proliferation and invasion in non-small cell lung cancer cells
X Wang, Z Chen - Oncology Research, 2016 - ncbi.nlm.nih.gov
Abstract Cullin 4B (CUL4B), a scaffold protein that assembles CRL4B ubiquitin ligase
complexes, was found to be overexpressed in many types of tumors. However, the …
complexes, was found to be overexpressed in many types of tumors. However, the …
Knockdown of CUL4A inhibits invasion and induces apoptosis in osteosarcoma cells
J Song, J Zhang, J Shao - International journal of …, 2015 - journals.sagepub.com
Cullin4A (CUL4A) is implicated in many cellular events including cell survival and growth.
However, the specific function and underlying mechanisms of CUL4A in cancer invasion …
However, the specific function and underlying mechanisms of CUL4A in cancer invasion …
Cullin1 is a novel prognostic marker and regulates the cell proliferation and metastasis in colorectal cancer
W Wang, Y Chen, J Deng, J Zhou, X Gu, Y Tang… - Journal of cancer …, 2015 - Springer
Purpose To investigate the precise function of Cullin1 (CUL1) in colorectal cancer (CRC).
Methods Immunohistochemistry was performed to test the expression of CUL1 on a CRC …
Methods Immunohistochemistry was performed to test the expression of CUL1 on a CRC …
[HTML][HTML] Cullin1 is a novel marker of poor prognosis and a potential therapeutic target in human breast cancer
J Bai, HM Yong, FF Chen, PJ Mei, H Liu, C Li, ZQ Pan… - Annals of oncology, 2013 - Elsevier
Background To investigate the role of Cullin1 (Cul1) in the development of breast cancer, we
examined the expression of Cul1 in breast cancer tissues and analyzed the correlation …
examined the expression of Cul1 in breast cancer tissues and analyzed the correlation …
CUL4A facilitates hepatocarcinogenesis by promoting cell cycle progression and epithelial-mesenchymal transition
Y Pan, B Wang, X Yang, F Bai, Q Xu, X Li, L Gao… - Scientific reports, 2015 - nature.com
CUL4A, a member of the CULLIN family, functions as a scaffold protein for an E3 ubiquitin
ligase. It was reported that the CUL4A gene showed amplification in some human primary …
ligase. It was reported that the CUL4A gene showed amplification in some human primary …