Efficacy of flecainide in the treatment of catecholaminergic polymorphic ventricular tachycardia: a randomized clinical trial

PJ Kannankeril, JP Moore, M Cerrone, SG Priori… - JAMA …, 2017 - jamanetwork.com
Importance Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a potentially
lethal genetic arrhythmia syndrome characterized by polymorphic ventricular tachycardia …

Flecainide therapy reduces exercise-induced ventricular arrhythmias in patients with catecholaminergic polymorphic ventricular tachycardia

C van der Werf, PJ Kannankeril, F Sacher… - Journal of the American …, 2011 - jacc.org
Objectives: This study evaluated the efficacy and safety of flecainide in addition to
conventional drug therapy in patients with catecholaminergic polymorphic ventricular …

Flecainide monotherapy is an option for selected patients with catecholaminergic polymorphic ventricular tachycardia intolerant of β-blockade

GJ Padfield, L AlAhmari, KVV Lieve, T AlAhmari… - Heart Rhythm, 2016 - Elsevier
Discussion We describe our initial experience of patients with RyR2-positive CPVT
successfully treated with flecainide monotherapy because of β-blocker intolerance. None of …

Effects of flecainide on exercise-induced ventricular arrhythmias and recurrences in genotype-negative patients with catecholaminergic polymorphic ventricular …

H Watanabe, C van der Werf, F Roses-Noguer, A Adler… - Heart rhythm, 2013 - Elsevier
BACKGROUND: Conventional therapy with beta-blockers is incompletely effective in
preventing arrhythmic events in patients with catecholaminergic polymorphic ventricular …

Successful treatment of catecholaminergic polymorphic ventricular tachycardia with flecainide: a case report and review of the current literature

C Pott, DG Dechering, F Reinke, A Muszynski… - Europace, 2011 - academic.oup.com
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited
arrhythmogenic disease that can cause sudden cardiac death due to ventricular fibrillation …

Therapeutic approach for patients with catecholaminergic polymorphic ventricular tachycardia: state of the art and future developments

C van der Werf, AH Zwinderman, AAM Wilde - Europace, 2012 - academic.oup.com
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited arrhythmia
syndrome characterized by bidirectional or polymorphic ventricular arrhythmias under …

Flecainide therapy suppresses exercise-induced ventricular arrhythmias in patients with CASQ2-associated catecholaminergic polymorphic ventricular tachycardia

A Khoury, I Marai, M Suleiman, M Blich, A Lorber… - Heart rhythm, 2013 - Elsevier
Background Calsequestrin-associated catecholaminergic polymorphic ventricular
tachycardia (CPVT2) can cause sudden death in young individuals in response to stress …

Flecainide prevents catecholaminergic polymorphic ventricular tachycardia in mice and humans

H Watanabe, N Chopra, D Laver, HS Hwang… - Nature medicine, 2009 - nature.com
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a potentially lethal
inherited arrhythmia syndrome in which drug therapy is often ineffective. We discovered that …

Catecholaminergic polymorphic ventricular tachycardia in children: analysis of therapeutic strategies and outcomes from an international multicenter registry

TM Roston, JM Vinocur, KR Maginot… - Circulation …, 2015 - Am Heart Assoc
Background—Catecholaminergic polymorphic ventricular tachycardia is an uncommon,
potentially lethal, ion channelopathy. Standard therapies have high failure rates and little is …

Clinical management of catecholaminergic polymorphic ventricular tachycardia: the role of left cardiac sympathetic denervation

GM De Ferrari, V Dusi, C Spazzolini, JM Bos… - Circulation, 2015 - Am Heart Assoc
Background—Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a genetic
disorder causing life-threatening arrhythmias whenever sympathetic activity increases. β …