Early observations, candidate gene studies and, more recently, genome-wide association
studies have shown that susceptibility to tuberculosis has a host genetic component …

Several candidate gene studies have provided evidence for a role of host genetics in
susceptibility to tuberculosis (TB). However, the results of these studies have been very …

Genetic factors are important contributors to the development of a wide range of complex or
multifactorial diseases. For example, if one has a close relative who died of ischemic heart …

Familial risk of tuberculosis (TB) has been recognized for centuries. Largely through studies
of mono-and dizygotic twin concordance rates, studies of families with Mendelian …

The evidence for a human genetic component in susceptibility to tuberculosis (TB) is
incontrovertible. Quite apart from studies of rare disease events illustrating the importance of …

Only a small fraction of individuals exposed to Mycobacterium tuberculosis develop clinical
tuberculosis (TB). Over the past century, epidemiological studies have shown that human …

Abstract Purpose of Review Tuberculosis (TB), caused by Mycobacterium tuberculosis
(MTB), remains a major public health threat globally. Several lines of evidence support a …

Methods This review is based upon a MEDLINE search of articles relevant to human genetic
susceptibility to mycobacteria. Results The impact of natural selection in shaping …

One of the primary goals of tuberculosis control programs is to interrupt the transmission of
Mycobacterium tuberculosis. The most effective way to accomplish this goal is to identify and …

Several epidemiology studies suggest that host genetic factors play important roles in
susceptibility, protection and progression of tuberculosis infection. Here we have reviewed …