Temporal dynamics of persistent germinal centers and memory B cell differentiation following respiratory virus infection
WT Yewdell, RM Smolkin, KT Belcheva, A Mendoza… - Cell reports, 2021 - cell.com
Following infection or immunization, memory B cells (MBCs) and long-lived plasma cells
provide humoral immunity that can last for decades. Most principles of MBC biology have …
provide humoral immunity that can last for decades. Most principles of MBC biology have …
Single-cell BCR and transcriptome analysis after influenza infection reveals spatiotemporal dynamics of antigen-specific B cells
B cell responses are critical for antiviral immunity. However, a comprehensive picture of
antigen-specific B cell differentiation, clonal proliferation, and dynamics in different organs …
antigen-specific B cell differentiation, clonal proliferation, and dynamics in different organs …
Broad dispersion and lung localization of virus-specific memory B cells induced by influenza pneumonia
HM Joo, Y He, MY Sangster - Proceedings of the National …, 2008 - National Acad Sciences
Although memory B cells (BMem) contribute significantly to resistance to infection, BMem
population characteristics that may relate to protective efficacy have received little attention …
population characteristics that may relate to protective efficacy have received little attention …
Lung-resident memory B cells established after pulmonary influenza infection display distinct transcriptional and phenotypic profiles
Recent studies have established that memory B cells, largely thought to be circulatory in the
blood, can take up long-term residency in inflamed tissues, analogous to widely described …
blood, can take up long-term residency in inflamed tissues, analogous to widely described …
Germinal center–dependent and–independent memory B cells produced throughout the immune response
C Viant, T Wirthmiller, MA ElTanbouly… - Journal of Experimental …, 2021 - rupress.org
Memory B cells comprise a heterogenous group of cells that differ in origin and phenotype.
During the early phases of the immune response, activated B cells can differentiate into IgM …
During the early phases of the immune response, activated B cells can differentiate into IgM …
The establishment of resident memory B cells in the lung requires local antigen encounter
SR Allie, JE Bradley, U Mudunuru, MD Schultz… - Nature …, 2019 - nature.com
Memory B cells are found in lymphoid and non-lymphoid tissues, suggesting that some may
be tissue-resident cells. Here we show that pulmonary influenza infection elicited lung …
be tissue-resident cells. Here we show that pulmonary influenza infection elicited lung …
Distinct germinal center selection at local sites shapes memory B cell response to viral escape
Y Adachi, T Onodera, Y Yamada, R Daio… - Journal of Experimental …, 2015 - rupress.org
Respiratory influenza virus infection induces cross-reactive memory B cells targeting
invariant regions of viral escape mutants. However, cellular events dictating the cross …
invariant regions of viral escape mutants. However, cellular events dictating the cross …
[HTML][HTML] Secondary influenza challenge triggers resident memory B cell migration and rapid relocation to boost antibody secretion at infected sites
Resident memory B (BRM) cells develop and persist in the lungs of influenza-infected mice
and humans; however, their contribution to recall responses has not been defined. Here, we …
and humans; however, their contribution to recall responses has not been defined. Here, we …
Memory B‐cell diversity: From early generation to tissue residency and reactivation
L Reusch, D Angeletti - European Journal of Immunology, 2023 - Wiley Online Library
Memory B cells (MBCs) have a crucial function in providing an enhanced response to
repeated infections. Upon antigen encounter, MBC can either rapidly differentiate to …
repeated infections. Upon antigen encounter, MBC can either rapidly differentiate to …
Do memory B cells form secondary germinal centers? Yes and no
MJ Shlomchik - Cold Spring Harbor perspectives in …, 2018 - cshperspectives.cshlp.org
Memory is the defining feature of the adaptive immune system. Humoral immune memory is
largely though not exclusively generated in the germinal center (GC), which spawns long …
largely though not exclusively generated in the germinal center (GC), which spawns long …
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- memory b cell response
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