Cyclin-dependent protein kinases (Cdks) play key roles in regulating cell division and gene
expression. Most Cdks require binding of a cyclin and phosphorylation by a Cdk-activating …

Activation of the cyclin-dependent kinases to promote cell cycle progression requires their
association with cyclins as well as phosphorylation of a threonine (residue 161 in human …

Eukaryotic cell cycle progression is controlled by a family of protein kinases known as cyclin-
dependent kinases (Cdks). Two steps are essential for Cdk activation: binding of a cyclin …

Cell cycle progression is dependent on the sequential activity of cyclin‐dependent kinases
(CDKs). For full activity, CDKs require an activating phosphorylation of a conserved residue …

Complete activation of most cyclin-dependent protein kinases (CDKs) requires
phosphorylation by the CDK-activating kinase (CAK). In the budding yeast, Saccharomyces …

Activation of a cyclin-dependent kinase (Cdk) requires its association with a cyclin subunit
and phosphorylation on a conserved residue by the Cdk-activating kinase (CAK). The …

Cyclin-dependent kinases (CDKs) function as central regulators of both the cell cycle and
transcription. CDK activation depends on phosphorylation by a CDK-activating kinase …

Cell cycle progression is regulated by cyclin-dependent kinases (cdks). The activity of cdks
is tightly controlled by several mechanisms, including binding of subunits to cdks (cyclins …

Cyclin-dependent kinases (CDKs) involved in cell cycle control require activation by
phosphorylation, but CDK-activating kinase (CAK) has diverged between metazoans and …

Cell cycle progression is controlled by the sequential functions of cyclin-dependent kinases
(cdks). Cdk activation requires phosphorylation of a key residue (on sites equivalent to Thr …