Oxidative stress and natural antioxidant mechanisms: the role in neurodegeneration. From molecular mechanisms to therapeutic strategies

A Karpińska, G Gromadzka - Postepy higieny i medycyny …, 2013 - europepmc.org
A lot of evidence exists that oxidative stress is the primary cause of neurodegeneration.
Neurons are more susceptible to oxidative damage than other cells due to their high oxygen …

Antioxidant protection: a promising therapeutic intervention in neurodegenerative disease

N Ghosh, R Ghosh, SC Mandal - Free Radical Research, 2011 - Taylor & Francis
Oxidative stress has been consistently linked to ageing-related neurodegenerative
diseases. Neurodegenerative diseases are characterized by progressive dysfunction and …

Neuroprotective effects of antioxidants in the management of neurodegenerative disorders: A literature review

Y Panahi, SM Rajaee, TP Johnston… - Journal of cellular …, 2019 - Wiley Online Library
It is proven that oxidative stress has a pivotal role in the process of neurodegeneration. The
use of antioxidants is an attractive method to prevent the incidence of neurodegenerative …

The influence of reactive oxygen species on the central nervous system

M Gutowicz - Postepy Higieny I Medycyny Doswiadczalnej (Online), 2011 - europepmc.org
Oxidative stress can be defined as a rise of oxidative potential or decrease of antioxidant
status. Oxidative stress is caused by reactive oxygen species (ROS) which are produced by …

The underlying role of oxidative stress in neurodegeneration: a mechanistic review

H Yaribeygi, Y Panahi, B Javadi… - CNS & Neurological …, 2018 - ingentaconnect.com
Background: Neurodegeneration is a condition in which progressive loss of function and
structure of neurons occurs. Several lines of evidence suggest that oxidative stress has a …

Neurodegeneration by oxidative stress: a review on prospective use of small molecules for neuroprotection

E Singh, G Devasahayam - Molecular Biology Reports, 2020 - Springer
The intricate physiology of many Central Nervous System (CNS) disorders points towards
oxidative damages of neurons. Various studies have established that oxidative stress is a …

Effect of natural exogenous antioxidants on aging and on neurodegenerative diseases

C Guerra-Araiza, AL Álvarez-Mejía… - Free Radical …, 2013 - Taylor & Francis
Aging and neurodegenerative diseases share oxidative stress cell damage and depletion of
endogenous antioxidants as mechanisms of injury, phenomena that are occurring at …

[PDF][PDF] Antioxidants as a preventive therapeutic option for age related neurodegenerative diseases

S Singh - Therapeutic Targets for Neurological Diseases, 2015 - Citeseer
Neurodegenerative disease term illustrate a range of conditions in which primarily neurons
get affected or die. Neurons are the building blocks of the central and peripheral nervous …

Neuroprotective effect of antioxidants in the brain

KH Lee, M Cha, BH Lee - International journal of molecular sciences, 2020 - mdpi.com
The brain is vulnerable to excessive oxidative insults because of its abundant lipid content,
high energy requirements, and weak antioxidant capacity. Reactive oxygen species (ROS) …

Oxidative stress in neurodegeneration: mechanisms and therapeutic perspectives

A Contestabile - Current topics in medicinal chemistry, 2001 - ingentaconnect.com
Neural tissue is especially sensitive to oxidative stress, which is considered a prominent
factor in both acute and chronic neurodegenerative diseases and traumatic brain insults. On …