Guards of the great wall: bacterial lysozyme inhibitors

L Callewaert, JM Van Herreweghe, L Vanderkelen… - Trends in …, 2012 - cell.com
Peptidoglycan is the major structural component of the bacterial cell wall. It provides
resistance against turgor and its cleavage by hydrolases such as lysozymes results in …

A new family of lysozyme inhibitors contributing to lysozyme tolerance in gram-negative bacteria

L Callewaert, A Aertsen, D Deckers… - PLoS …, 2008 - journals.plos.org
Lysozymes are ancient and important components of the innate immune system of animals
that hydrolyze peptidoglycan, the major bacterial cell wall polymer. Bacteria engaging in …

Structural basis for the recognition of lysozyme by MliC, a periplasmic lysozyme inhibitor in Gram-negative bacteria

S Yum, MJ Kim, Y Xu, XL Jin, HY Yoo, JW Park… - Biochemical and …, 2009 - Elsevier
Lysozymes are an important component of the innate immune system of animals that
hydrolyze peptidoglycan, the major bacterial cell wall constituent. Many bacteria have …

Lysozyme inhibitor conferring bacterial tolerance to invertebrate type lysozyme

JM Van Herreweghe, L Vanderkelen… - Cellular and molecular …, 2010 - Springer
Abstract Invertebrate (I-) type lysozymes, like all other known lysozymes, are dedicated to
the hydrolysis of peptidoglycan, the major bacterial cell wall polymer, thereby contributing to …

Identification of a bacterial inhibitor against g-type lysozyme

L Vanderkelen, JM Van Herreweghe… - Cellular and Molecular …, 2011 - Springer
Lysozymes are antibacterial effectors of the innate immune system in animals that hydrolyze
peptidoglycan. Bacteria have evolved protective mechanisms that contribute to lysozyme …

Role of Lysozyme Inhibitors in the Virulence of Avian Pathogenic Escherichia coli

L Vanderkelen, E Ons, JM Van Herreweghe… - 2012 - journals.plos.org
Lysozymes are key effectors of the animal innate immunity system that kill bacteria by
hydrolyzing peptidoglycan, their major cell wall constituent. Recently, specific inhibitors of …

Molecular basis of bacterial defense against host lysozymes: X-ray structures of periplasmic lysozyme inhibitors PliI and PliC

S Leysen, JM Van Herreweghe, L Callewaert… - Journal of molecular …, 2011 - Elsevier
Lysozymes play a key role in the innate immune system of vertebrates and invertebrates by
hydrolyzing peptidoglycan, a vital component of the bacterial cell wall. Gram-negative …

The non‐enzymatic microbicidal activity of lysozymes

K Düring, P Porsch, A Mahn, O Brinkmann… - FEBS …, 1999 - Wiley Online Library
T4 lysozyme was thought to destroy bacteria by its muramidase activity. However, we
demonstrate here that amphipathic helix stretches in the C‐terminus of T4 lysozyme mediate …

From bacterial killing to immune modulation: Recent insights into the functions of lysozyme

SA Ragland, AK Criss - PLoS pathogens, 2017 - journals.plos.org
Lysozyme is a cornerstone of innate immunity. The canonical mechanism for bacterial killing
by lysozyme occurs through the hydrolysis of cell wall peptidoglycan (PG). Conventional …

Structural basis of bacterial defense against g-type lysozyme-based innate immunity

S Leysen, L Vanderkelen, SD Weeks… - Cellular and molecular …, 2013 - Springer
Gram-negative bacteria can produce specific proteinaceous inhibitors to defend themselves
against the lytic action of host lysozymes. So far, four different lysozyme inhibitor families …