Polycystic ovary syndrome (PCOS) is typically characterized by a polycystic ovarian
morphology, hyperandrogenism, ovulatory dysfunction, and infertility. Furthermore, PCOS …

Polycystic ovary syndrome (PCOS) is one of the most common reproductive endocrine
disorders accompanied by obvious metabolic abnormalities. Lower-quality oocytes and …

Purpose: Wnt pathways control key biological processes that potentially impact on tumor
progression and patient survival. We aimed to evaluate DNA methylation at promoter CpG …

Objective To evaluate the epigenetic consequence on the methylome and subsequent
transcriptome in euploid blastocysts of male-factor (MF) infertility patients. Design …

To identify epigenetic-based biomarkers for diagnosis of ovarian cancer we performed
MeDIP-Chip in A2780 and CaOV3 ovarian cancer cell lines. Validation by Sequenom …

Infertility affects a significant number of couples worldwide and its incidence is increasing.
While assisted reproductive technologies (ART) have revolutionized the treatment …

Polycystic ovary syndrome (PCOS) is characterized by increased ovarian androgen
secretion, anovulatory infertility due to arrested folliculogenesis, and is frequently found in …

DNA methylation contributes to tumor formation, development and metastasis. Epigenetic
dysregulation of stem cells is thought to predispose to malignant development. The clinical …

Abstract STUDY QUESTION Does imprinted DNA methylation or imprinted gene expression
differ between human blastocysts from conventional ovarian stimulation (COS) and an …

STUDY QUESTION Are there any differences between in vivo (IVV) and in vitro (IVT)
matured metaphase II (MII) oocytes at the molecular level? SUMMARY ANSWER Between …