Positive transforming growth factor-β activated kinase-1 expression has an unfavorable impact on survival in T3N1-3M0 esophageal squamous cell carcinomas

J Wen, Y Hu, KJ Luo, H Yang, SS Zhang… - The Annals of thoracic …, 2013 - Elsevier
BACKGROUND: Transforming growth factor-β activated kinase-1 (TAK1) is a
serine/threonine kinase in the mitogen-activated protein kinase kinase family. Previous …

The expression and clinical significance of TAK1 in esophageal cancer

F Qiao, Q Tong - The Journal of Practical Medicine, 2014 - pesquisa.bvsalud.org
Objective To examine the expression of transforming growth factor β (TGF-β) activated
kinase 1 (TAK1) in esophageal organization and the impact of TAK1 expression on …

Transforming growth factor-β activated kinase 1 (Tak1) is activated in hepatocellular carcinoma, mediates tumor progression, and predicts unfavorable outcome

DA Ridder, LL Urbansky, HR Witzel… - Cancers 14 … - openscience.ub.uni-mainz.de
Although knowledge on inflammatory signaling pathways driving cancer initiation and
progression has been increasing, molecular mechanisms in hepatocarcinogenesis are still …

[HTML][HTML] TAB3 promotes human esophageal squamous cell carcinoma proliferation and invasion via the NF‑κB pathway

J Zhao, L Gai, Y Gao, W Xia, D Shen… - Oncology …, 2018 - spandidos-publications.com
Esophageal squamous cell carcinoma (ESCC) has become one of the most common
causes of cancer‑associated mortality worldwide. Transforming growth factor‑activated …

[HTML][HTML] Transforming growth factor-β activated kinase 1 (Tak1) is activated in hepatocellular carcinoma, mediates tumor progression, and predicts unfavorable …

DA Ridder, LL Urbansky, HR Witzel, M Schindeldecker… - Cancers, 2022 - mdpi.com
Simple Summary Chronic inflammation is known to drive cancer initiation and progression in
the liver and other organs. In different genetic mouse models, the role of the pro …

[HTML][HTML] Expression and function of transforming growth factor‑β‑activated protein kinase 1 in gastric cancer

Y Yang, Y Qiu, M Tang, Z Wu… - Molecular medicine …, 2017 - spandidos-publications.com
The present study aimed to investigate the expression and role of transforming growth factor
(TGF)‑β‑activated protein kinase 1 (TAK1) in human gastric cancer. Immunohistochemistry …

[HTML][HTML] Expression of TAK1/TAB1 expression in non-small cell lung carcinoma and adjacent normal tissues and their clinical significance

J Zhu, Q Li, JT He, GY Liu - International Journal of Clinical and …, 2015 - ncbi.nlm.nih.gov
The purpose of this study was to investigate the expression of transforming growth factor
beta-activated kinase 1 (TAK1) and its activation ligand, TAK1-binding protein 1 (TAB1), in …

[HTML][HTML] The role of TAK1 expression in thyroid cancer

P Lin, W Niu, C Peng, Z Zhang, J Niu - International Journal of …, 2015 - ncbi.nlm.nih.gov
Objective: To investigate the expression, significance, and role of transforming growth factor
β-activated kinase 1 (TAK1) in human thyroid cancer tissue. Methods: The data of 101 …

[HTML][HTML] TAK1 regulates hepatic cell survival and carcinogenesis

YS Roh, J Song, E Seki - Journal of gastroenterology, 2014 - Springer
Abstract TGF-β-activated kinase 1 (TAK1 or MAP3K7) is an intracellular hub molecule that
regulates both nuclear factor-κB (NF-κB) and mitogen-activated protein kinase (MAPK) …

Dominant-negative TAK1 induces c-Myc and G0 exit in liver

CA Bradham, E Hatano… - American Journal of …, 2001 - journals.physiology.org
Transforming growth factor-β (TGF-β)-activated kinase 1 (TAK1), a serine/threonine kinase,
is reported to function in the signaling pathways of TGF-β, interleukin 1, and ceramide …