Experimental autoimmune prostatitis induces chronic pelvic pain

CN Rudick, AJ Schaeffer… - American Journal of …, 2008 - journals.physiology.org
Pain is the hallmark of patients with chronic prostatitis (CP) and chronic pelvic pain
syndrome (CPPS). Despite numerous hypotheses, the etiology and pathogenesis remain …

A novel murine model of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) induced by immunization with a spermine binding protein (p25) peptide

CZ Altuntas, F Daneshgari, E Veizi… - American Journal …, 2013 - journals.physiology.org
The pathophysiology of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is poorly
understood. Inflammatory and autoimmune mechanisms may play a role. We developed a …

Immunological mechanisms underlying chronic pelvic pain and prostate inflammation in chronic pelvic pain syndrome

ML Breser, FC Salazar, VE Rivero… - Frontiers in …, 2017 - frontiersin.org
Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is the most common urologic
morbidity in men younger than 50 years and is characterized by a diverse range of pain and …

Chronic pelvic pain development and prostate inflammation in strains of mice with different susceptibility to experimental autoimmune prostatitis

ML Breser, RD Motrich, LR Sanchez, VE Rivero - The Prostate, 2017 - Wiley Online Library
BACKGROUND Experimental autoimmune prostatitis (EAP) is an autoimmune inflammatory
disease of the prostate characterized by peripheral prostate‐specific autoimmune responses …

Experimental autoimmune prostatitis induces microglial activation in the spinal cord

L Wong, JD Done, AJ Schaeffer, P Thumbikat - The Prostate, 2015 - Wiley Online Library
BACKGROUND The pathogenesis of chronic prostatitis/chronic pelvic pain syndrome is
unknown and factors including the host's immune response and the nervous system have …

[HTML][HTML] Autonomic nervous system dysfunction is related to chronic prostatitis/chronic pelvic pain syndrome

H He, H Luo, B Qian, H Xu, G Zhang… - The World Journal of …, 2024 - ncbi.nlm.nih.gov
Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a common and non-lethal
urological condition with painful symptoms. The complexity of CP/CPPS's pathogenesis and …

The role of phenotyping in chronic prostatitis/chronic pelvic pain syndrome

BA Mahal, JM Cohen, SA Allsop, JB Moore… - Current urology …, 2011 - Springer
Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a chronic pain syndrome
identified by the presence of noninfectious pelvic or perineal pain lasting longer than 3 …

Chronic pelvic pain and prostate inflammation in rat experimental autoimmune prostatitis: effect of a single treatment with phosphodiesterase 5 inhibitors on chronic …

M Kurita, H Yamaguchi, K Okamoto, T Kotera… - The …, 2018 - Wiley Online Library
Background Experimental autoimmune prostatitis (EAP) is most often used as a nonbacterial
model of chronic prostatitis/chronic pelvic pain. We investigated the development of chronic …

Immune mediators of chronic pelvic pain syndrome

SF Murphy, AJ Schaeffer, P Thumbikat - Nature Reviews Urology, 2014 - nature.com
The cause of chronic pelvic pain syndrome (CPPS) has yet to be established. Since the late
1980s, cytokine, chemokine, and immunological classification studies using human samples …

Nociceptive and inflammatory mediator upregulation in a mouse model of chronic prostatitis

ES Schwartz, A Xie, JH La, GF Gebhart - Pain, 2015 - journals.lww.com
Chronic nonbacterial prostatitis, characterized by genitourinary pain in the pelvic region in
the absence of an identifiable cause, is common in adult males. Surprisingly, the sensory …