Methotrexate (MTX) is widely used in the treatment of numerous malignancies; however, its
use is associated with marked hepatotoxicity. Herein, we assessed the possible …

This study targeted to examine the protective effects of acetovanillone (AV) against
methotrexate (MTX)‐induced hepatotoxicity. Thirty‐two rats were allocated into four groups …

Abstract Acute Liver Injury (ALI), a highly prevalent liver disease in the last two decades, but
there is still no effective treatment for it. As a member of Tibetan medicine, Swertia chirayita …

Methotrexate (MTX) therapy encounters significant limitations due to the significant concern
of drug-induced liver injury (DILI), which poses a significant challenge to its usage. To …

Phenytoin-induced liver injury (PHT ILII) is a serious condition that may necessitate
discontinuation of the drug. This study investigates the mechanisms of PHT ILII and …

Aims Methotrexate (MTX) is an efficient cytotoxic drug used against various carcinogenic,
inflammatory and autoimmune diseases; however, the hepatotoxicity of MTX limits its use …

The usage of the chemotherapeutic agent methotrexate (MTX) was associated with
hepatotoxicity that minimized its clinical use. The Ginkgo biloba extract (GBE) was used …

Background and Objective: A Tibetan traditional herb named Swertia mussotii Franch., also
called “Zangyinchen” by the local people of the Qinghai-Tibet area, has been used to protect …

Abstract Background/Aims: Swertiamarin (STM), the main bioactive component in Swertia
mussotii Franch (Gentianaceae), has been shown to exert hepatoprotective effects on …

Despite unprecedented advances in modern medicine, no safe and effective drug is
available to date for oral administration to combat drug-induced liver injury, which is a vital …