PTEN is a PIP3 phosphatase that antagonizes oncogenic PI3-kinase signalling. Due to its
critical role in suppressing the potent signalling pathway, it is one of the most mutated …

PTEN is a phosphatase which metabolises PIP 3, the lipid product of PI 3-Kinase, directly
opposing the activation of the oncogenic PI3K/AKT/mTOR signalling network. Accordingly …

PTEN dysfunction plays a crucial role in the pathogenesis of hereditary and sporadic
cancers. Here, we show that PTEN homodimerizes and, in this active conformation, exerts …

The PTEN tumor suppressor is frequently affected in cancer cells, and inherited PTEN
mutation causes cancer-susceptibility conditions such as Cowden syndrome. PTEN acts as …

PTEN is the most important negative regulator of the PI3K signaling pathway. In addition to
its canonical, PI3K inhibition-dependent functions, PTEN can also function as a tumor …

The PTEN (phosphatase and tensin homologue deleted on chromosome 10) tumour
suppressor is a PI (phosphoinositide) 3-phosphatase that can inhibit cellular proliferation …

Phosphatase and tensin homolog (PTEN), which negatively regulates tumorigenic
phosphatidylinositol (3, 4, 5)-trisphosphate (PIP3) signaling, is a commonly mutated tumor …

As the phosphoinositol-3-kinase antagonist in the PI3K pathway, the PTEN tumor
suppressor exerts phosphatase activity on diacylphosphatidylinositol triphosphate in the …

Tumor suppressor PTEN controls genomic stability and inhibits tumorigenesis. The N-
terminal phosphatase domain of PTEN antagonizes the PI3K/AKT pathway, but its C …

The PTEN tumour suppressor gene is mutated frequently in many malignancies and its
importance in the development of cancer is probably underestimated. As the primary …