Integrase inhibitors (INIs) are a potent option for HIV treatment. Limited data exist on INI
resistance in West Africa, particularly in children living with HIV/AIDS. We determined the …

Background Although biochemical analysis of HIV-1 integrase enzyme suggested the use of
integrase inhibitors (INIs) against HIV-1C, different viral subtypes may favor different …

Major mutations associated with HIV-I integrase inhibitors (INI) resistance are rare in INI-
naive patients. However, polymorphisms at positions that may influence the genetic barrier …

Previously used as part of salvage therapy, integrase strand transfer inhibitors (INSTIs) have
become part of the preferred antiretroviral therapy (ART) first-line regimen in most low-to …

Drug resistance has been recognized in all available therapeutic class of medications for the
management of human immunodeficiency virus‐1 (HIV‐1) infected patients. This makes the …

Background Antiretroviral therapy for HIV-2 infection is hampered by intrinsic resistance to
many of the drugs used to treat HIV-1. Limited studies suggest that the integrase inhibitors …

The World Health Organization (WHO) has put forth recommendations for the use of
integrase (IN) strand transfer inhibitors (INSTIs) to be part of the first-line combination …

HIV‐1 genetic diversity and drug resistance mutations remain public health challenges
especially in regions where treatment is limited. The aim of this study was to characterize the …

Abstract Objectives: Resistance-associated mutations (RAMs) in the integrase of different
HIV-1 subtypes were investigated in a cohort of patients never exposed to integrase strand …

Tanzania has recently adapted World Health Organization antiretroviral guidelines that
include integrase strand transfer inhibitors (INSTIs) in the first-line regimen. However, there …