Cancer risk of heterocyclic amines in cooked foods: an analysis and implications for research

DW Layton, KT Bogen, MG Knize, FT Hatch… - …, 1995 - academic.oup.com
Heterocyclic amines (HAs) are formed as pyrolysis products during the cooking of
meats/fish. These substances are potent mutagens in the Ames/Salmonella assay and are …

Problems associated with the determination of heterocyclic amines in cooked foods and human exposure

K Skog - Food and Chemical Toxicology, 2002 - Elsevier
Epidemiological studies have shown diet to be an important factor in the global variation of
human cancer rates. The presence of mutagenic/carcinogenic heterocyclic aromatic amines …

Biological significance of trace levels of mutagenic heterocyclic aromatic amines in human diet: a critical review

B Stavric - Food and Chemical Toxicology, 1994 - Elsevier
Cooking of protein-rich foods may induce the formation of a series of heterocyclic aromatic
amines (HAAs) that have been found to be mutagens and carcinogens. Despite very potent …

US dietary exposures to heterocyclic amines

KT Bogen, GA Keating - Journal of Exposure Science & Environmental …, 2001 - nature.com
Heterocyclic amines (HAs) formed in fried, broiled or grilled meats are potent mutagens that
increase rates of colon, mammary, prostate and other cancers in bioassay rodents. Studies …

Heterocyclic amine content in beef cooked by different methods to varying degrees of doneness and gravy made from meat drippings

R Sinha, N Rothman, CP Salmon, MG Knize… - Food and Chemical …, 1998 - Elsevier
Meats cooked at high temperatures sometimes contain heterocyclic amines (HCAs) that are
known mutagens and animal carcinogens, but their carcinogenic potential in humans has …

Exposure assessment of heterocyclic amines (HCAs) in epidemiologic studies

R Sinha, N Rothman - Mutation Research/Fundamental and Molecular …, 1997 - Elsevier
The carcinogenic potential of heterocyclic amines (HCAs) in humans has yet to be
established. Epidemiologic studies of colon cancer using crude surrogates for HCAs …

Formation and human risk of carcinogenic heterocyclic amines formed from natural precursors in meat

MG Knize, JS Felton - Nutrition reviews, 2005 - academic.oup.com
A group of heterocyclic amines that are mutagens and rodent carcinogens form when meat
is cooked to medium and well-done states. The precursors of these compounds are natural …

An epidemiologic approach to studying heterocyclic amines

R Sinha - … Research/Fundamental and Molecular Mechanisms of …, 2002 - Elsevier
Diets containing substantial amounts of red meat may increase the risk of colorectal,
pancreatic, breast, prostate, and renal cancer. The association with red meat intake may be …

Heterocyclic amine content in fast-food meat products

MG Knize, R Sinha, N Rothman, ED Brown… - Food and Chemical …, 1995 - Elsevier
Heterocyclic aromatic amines are sometimes formed during the cooking of muscle meats,
and their mutagenic and carcinogenic effects are of potential concern in the aetiology of …

Carcinogenic heterocyclic amines in model systems and cooked foods: a review on formation, occurrence and intake

KI Skog, MAE Johansson, MI Jägerstad - Food and chemical Toxicology, 1998 - Elsevier
Frying or grilling of meat and fish products may generate low ppb levels of mutagenic/
carcinogenic heterocyclic amines (HAs). Many heterocyclic amines are formed via the …