Large-scale proteomic and metabolomic technologies are increasingly gaining attention for
their use in the diagnosis of human disease. In order to ensure the statistical power of …

The recent thriving development of biobanks and associated high-throughput phenotyping
studies requires the elaboration of large-scale approaches for monitoring biological sample …

Sample preparation remains a challenge in untargeted metabolomics studies and no
method currently results in complete extraction of all metabolite classes in human plasma …

Blood is widely used for discovery metabolomics to search for disease biomarkers.
However, blood sample matrix can have a profound effect on metabolome analysis, which …

A critical question facing the field of metabolomics is whether data obtained from different
centers can be effectively compared and combined. An important aspect of this is the …

Every day, analytical and bio-analytical chemists make sustained efforts to improve the
sensitivity, specificity, robustness, and reproducibility of their methods. Especially in targeted …

In metabolomic research, blood plasma and serum have been considered to possess similar
compositions and properties. Their perceived equivalence has resulted in researchers …

BACKGROUND Metabolomics is a powerful tool that is increasingly used in clinical
research. Although excellent sample quality is essential, it can easily be compromised by …

Introduction Analysis of blood for the evaluation of clinically relevant biomarkers requires
precise collection and sample handling by phlebotomists and laboratory staff. An important …

BACKGROUND Metabolomics is a valuable tool with applications in almost all life science
areas. There is an increasing awareness of the essential need for high-quality biospecimens …