Meta-analysis identifies six new susceptibility loci for atrial fibrillation

PT Ellinor, KL Lunetta, CM Albert, NL Glazer… - Nature …, 2012 - nature.com
Atrial fibrillation is a highly prevalent arrhythmia and a major risk factor for stroke, heart
failure and death. We conducted a genome-wide association study (GWAS) in individuals of …

Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation

IE Christophersen, M Rienstra, C Roselli, X Yin… - Nature …, 2017 - nature.com
Atrial fibrillation affects more than 33 million people worldwide and increases the risk of
stroke, heart failure, and death,. Fourteen genetic loci have been associated with atrial …

[PDF][PDF] Genome-wide study of atrial fibrillation identifies seven risk loci and highlights biological pathways and regulatory elements involved in cardiac development

JB Nielsen, LG Fritsche, W Zhou, TM Teslovich… - The American Journal of …, 2018 - cell.com
Atrial fibrillation (AF) is a common cardiac arrhythmia and a major risk factor for stroke, heart
failure, and premature death. The pathogenesis of AF remains poorly understood, which …

Genome-wide association studies of atrial fibrillation: past, present, and future

MF Sinner, PT Ellinor, T Meitinger… - Cardiovascular …, 2011 - academic.oup.com
Genome-wide association studies (GWAS) for atrial fibrillation (AF) have identified three
distinct genetic loci on chromosomes 1q21, 4q25, and 16q22 that are associated with the …

Multi-ethnic genome-wide association study for atrial fibrillation

C Roselli, MD Chaffin, LC Weng, S Aeschbacher… - Nature …, 2018 - nature.com
Atrial fibrillation (AF) affects more than 33 million individuals worldwide and has a complex
heritability. We conducted the largest meta-analysis of genome-wide association studies …

Genetics of atrial fibrillation in 2020: GWAS, genome sequencing, polygenic risk, and beyond

C Roselli, M Rienstra, PT Ellinor - Circulation research, 2020 - Am Heart Assoc
Atrial fibrillation is a common heart rhythm disorder that leads to an increased risk for stroke
and heart failure. Atrial fibrillation is a complex disease with both environmental and genetic …

Common variation in atrial fibrillation: navigating the path from genetic association to mechanism

NR Tucker, S Clauss, PT Ellinor - Cardiovascular research, 2016 - academic.oup.com
Atrial fibrillation (AF) is the most common cardiac arrhythmia with well-established clinical
and genetic risk components. Genome-wide association studies (GWAS) have identified 17 …

Emerging directions in the genetics of atrial fibrillation

NR Tucker, PT Ellinor - Circulation research, 2014 - Am Heart Assoc
Atrial fibrillation (AF) is the most common arrhythmia and is associated with increased
morbidity. As the population ages and the prevalence of AF continues to rise, the …

Integrating genetic, transcriptional, and functional analyses to identify 5 novel genes for atrial fibrillation

MF Sinner, NR Tucker, KL Lunetta, K Ozaki, JG Smith… - Circulation, 2014 - Am Heart Assoc
Background—Atrial fibrillation (AF) affects> 30 million individuals worldwide and is
associated with an increased risk of stroke, heart failure, and death. AF is highly heritable …

Genetics of atrial fibrillation: state of the art in 2017

D Fatkin, CF Santiago, IG Huttner, SA Lubitz… - Heart, Lung and …, 2017 - Elsevier
Genetic variation is an important determinant of atrial fibrillation (AF) susceptibility.
Numerous rare variants in protein-coding sequences of genes have been associated with …