Sperm are a highly specialized cell type derived to deliver the paternal haploid genome to
the oocyte. The epigenetic, or gene regulatory, properties and mechanisms of the sperm …

DNA repair has long been considered impossible in human spermatozoa due to the high
level of DNA compaction observed in these cells. However, detailed examination of the base …

Recent studies have indicated that epigenetic alterations are critical for normal function and
development of spermatozoa during the fertilization process. This review will focus on the …

Purpose Sperm DNA fragmentation has been suggested as a marker for infertility diagnosis
and prognosis. Hence, understanding its impact on male physiology and post-genomic …

Correspondence to: Dr. A. Agarwal, Ph. D., HCLD, Director, Center for Advanced Research
in Human Reproduction, Infertility and Sexual Function, Glickman Urological Institute, The …

Nuclear DNA damage in spermatozoa could potentially have a major impact on the
fertilizing capacity of these cells, their ability to establish a normal pattern of embryonic …

Sperm DNA fragmentation (sDF) represents a threat to male fertility, human reproduction
and the health of the offspring. The causes of sDF are still unclear, even if apoptosis …

Sperm DNA integrity is essential for the accurate transmission of genetic information. It has a
highly compact and complex structure and is capable of decondensation—features that must …

Sperm is not a simple carrier of paternal genetic information but its role extends clearly
beyond fertilization. Integrity of sperm genome is an essential pre-requisite for birth of …

Background The assisted reproductive techniques aimed to assist infertile couples have
their own offspring carry significant risks of passing on molecular defects to next …