What are the treatment remission, response and extent of improvement rates after up to four trials of antidepressant therapies in real-world depressed patients? A …

HE Pigott, T Kim, C Xu, I Kirsch, J Amsterdam - BMJ open, 2023 - bmjopen.bmj.com
Objective Reanalyse the patient-level data set of the Sequenced Treatment Alternatives to
Relieve Depression (STAR* D) study with fidelity to the original research protocol and …

Sequenced treatment alternatives to relieve depression (STAR* D): rationale and design

AJ Rush, M Fava, SR Wisniewski, PW Lavori… - Controlled clinical …, 2004 - Elsevier
STAR* D is a multisite, prospective, randomized, multistep clinical trial of outpatients with
nonpsychotic major depressive disorder. The study compares various treatment options for …

STAR* D: revising conventional wisdom

AJ Rush, D Warden, SR Wisniewski, M Fava… - CNS drugs, 2009 - Springer
Abstract The STAR* D (Sequenced Treatment Alternatives to Relieve Depression) study
used a series of sequenced, randomized treatment trials following a first and, if needed …

Can phase III trial results of antidepressant medications be generalized to clinical practice? A STAR* D report

SR Wisniewski, AJ Rush… - American Journal of …, 2009 - Am Psychiatric Assoc
Objective: Phase III clinical trials for depression enroll participants with major depressive
disorder according to stringent inclusion and exclusion criteria. These patients may not be …

What are the implications of the STAR* D trial for primary care? A review and synthesis

NN Huynh, RS McIntyre - Primary care companion to the Journal of …, 2008 - psychiatrist.com
Background: Although results of the Sequenced Treatment Alternatives to Relieve
Depression (STAR* D) trial have been widely disseminated to mental health care providers …

Translating science into service: lessons learned from the Sequenced Treatment Alternatives to Relieve Depression (STAR* D) study

N Sussman - Primary care companion to the Journal of clinical …, 2007 - psychiatrist.com
Objective: The purpose of this review is to summarize lessons learned from, and limitations
of, the Sequenced Treatment Alternatives to Relieve Depression (STAR* D) trial, focusing on …

The aims and design of the Sequenced Treatment Alternatives to Relieve Depression (STAR* D) study

BN Gaynes, L Davis, AJ Rush… - Primary …, 2005 - utsouthwestern.elsevierpure.com
Major depressive disorder is expected to become the second leading cause of disability
worldwide by the year 2020. A large proportion of this disability can be attributed to the large …

Sequenced treatment alternatives to relieve depression (STAR* D): lessons learned

S Zisook, K Ganadjian, C Moutier… - The Journal of clinical …, 2008 - psychiatrist.com
Sequenced Treatment Alternatives toRelieve Depression (STAR* D), the largestprospective,
randomized antidepressanttreatment trial to date in outpatients withmajor depressive …

[HTML][HTML] Strategic use of new generation antidepressants for depression: SUN (^ _^) D study protocol

TA Furukawa, T Akechi, S Shimodera, M Yamada… - Trials, 2011 - Springer
Background After more than half a century of modern psychopharmacology, with billions of
dollars spent on antidepressants annually world-wide, we lack good evidence to guide our …

Limitations in efficacy of antidepressant monotherapy

AJ Rush - Journal of Clinical Psychiatry, 2007 - psychiatrist.com
Treatment for major depressive disorder does not achieve remission in about 50% of
patients following 2 treatment trials. Researchers conducted the Sequenced Treatment …