As a part of our searching for natural human carboxylesterase 2 (human CES 2) inhibitors
from traditional Chinese medicine, we found that the extract of Alisma orientale significantly …

Twelve new and 10 known protostane triterpenoids were isolated from the rhizome of Alisma
orientale. Their structures were elucidated based on physical data analyses, including UV …

Abstract Human carboxylesterase 1 (CES1), primarily expressed in the liver and adipocytes,
is responsible for the hydrolysis of endogenous esters (such as cholesteryl esters and …

In our search for natural human carboxylesterase 2 (hCE 2) inhibitors from natural products,
we investigated inhibitory effects and mechanisms of flavonoids (1–16) against hCE 2. The …

In this study, forty-nine kinds of traditional Chinese medicines (TCMs) were evaluated for
their inhibitory activities against human carboxylesterase 2 (HCE 2) using a human liver …

The rhizomes of Alisma orientalis have been used for centuries in China and other Asian
countries as an effective herbal remedy. The phytochemical investigation of A. orientalis and …

Abstract Background Carboxylesterases (CEs) belong to the serine hydrolase family, and
are in charge of hydrolyzing chemicals with carboxylic acid ester and amide functional …

Human carboxylesterases (hCEs) are key enzymes from the serine hydrolase superfamily.
Among all identified hCEs, human carboxylesterase 2 (hCE2) plays crucial roles in the …

Abstract Human Carboxylesterase 2A (hCES2A), one of the most important serine
hydrolases, plays crucial roles in the hydrolysis and the metabolic activation of a wide range …

The phytochemical investigation of Andrographis paniculata resulted in the isolation of a
novel 15-spiro diterpenoid dimer bisandrographolide G (1). Its structure was determined by …