The first clinical description of sickle cell anemia was published in 1910 by Herri~ k?~ who
reported some of the clinical and hematologic manifestations of the disorder in a 20-year-old …

Sickle cell disease results in significant morbidity and mortality for those affected with this
disease. Despite the fact that every case of sickle cell disease results from the same genetic …

Sickle cell anaemia was recognized in Africa as a disorder of the blood long before James
Herrick's description of the sickling red cells in 1910. It is, therefore, appropriate that a book …

Although sickle cell anemia was the first molecular disease to be identified, its complex and
fascinating pathophysiology is still not fully understood. A single mutation in the beta-globin …

In the United States, sickle cell disease affects approximately 1 in 350 African-American
newborn infants each year, and approximately 72,000 individuals total. Sickle cell disease is …

Sickle cell disease (SCD) is a complex, clinically heterogeneous disorder affecting
approximately 100,000 individuals in the United States and millions worldwide. The disease …

Although more is known about sickle cell disease than about any other inherited disease, no
cure for it exists. In America alone, about one in 375 who are of African ancestry is born with …

The discovery of the molecular basis of sickle cell disease was an important landmark in
molecular medicine. The modern tools of molecular and cellular biology have refined our …

Sickle cell disease is an autosomal recessive, multisystem disorder, characterised by
chronic haemolytic anaemia, painful episodes of vaso-occlusion, progressive organ failure …

Sickle cell disease and its variants constitute the most common inherited blood disorders
affecting millions of individuals worldwide. Significant information regarding the nature of the …