Potassium depletion affects AQP2 expression and the cellular composition of the kidney
collecting duct. This, in turn, contributes to the development of a secondary form of …

Background/Aim: In a rat model, lithium treatment is associated with polyuria and severe
downregulation of aquaporin-2 (AQP2) protein in the inner medulla (IM) or in the whole …

The involvement of prostaglandin E2 (PGE2), adenosine 3', 5'-cyclic monophosphate
(cAMP), and vasopressin in lithium-induced polyuria was investigated in rats. Administration …

Fundamental kidney physiology research can provide important insight into how the kidney
works and suggest novel therapeutic opportunities to treat human diseases. This is …

Abstract P2Y 12 receptor (P2Y 12-R) signaling is mediated through G i, ultimately reducing
cellular cAMP levels. Because cAMP is a central modulator of arginine vasopressin (AVP) …

Drug-induced polyuria and polydipsia have been recognized with increasing frequency
during the past five years. Several drugs, such as lithium, had been in use for many years …

Vasopressin (AVP)-stimulated translocation and transcription of aquaporin-2 (AQP2) water
channels in renal principal cells is essential for urine concentration. Twenty percent of …