Chemokine receptors mediate migration of immune cells into the liver, thereby promoting
liver inflammation. C‐C motif chemokine receptor (CCR) 9+ macrophages are crucial in the …

Chemokines critically control the infiltration of immune cells upon liver injury, thereby
promoting hepatic inflammation and fibrosis. The chemokine receptor CCR8 can affect …

Chronic liver injury promotes hepatic inflammation, representing a prerequisite for organ
fibrosis. We hypothesized a contribution of chemokine receptor CCR6 and its ligand …

Activation of hepatic stellate cells in response to chronic inflammation represents a crucial
step in the development of liver fibrosis. However, the molecules involved in the interaction …

Inflammation, which is mediated by leukocyte trafficking and activation, plays a prominent
role in the pathogenesis of acute and chronic liver injury. Chemokines are critical mediators …

Liver fibrosis is associated with infiltrating immune cells and activation of hepatic stellate
cells. We here aimed to investigate the effects of the CC chemokine CCL3, also known as …

Chemokines and chemokine receptors contribute to the migration of hepatic stellate cells
(HSCs) and Kupffer cells, two key cell types in fibrogenesis. Here, we investigate the role of …

Hepatic fibrosis develops as a response to chronic liver injury and almost exclusively occurs
in a proinflammatory environment. However, the role of inflammatory mediators in fibrogenic …

Sustained inflammation upon chronic liver injury induces the development of liver fibrosis in
mice and men. Experimental models of liver fibrosis highlight the importance of hepatic …

Antagonism of the chemokine Ccl5 ameliorates experimental liver fibrosis in mice. Marie-
Luise Berres, Rory R. Koenen, Anna Rueland, Mirko Moreno Zaldivar, Daniel Heinrichs …