Pain is often perceived an unpleasant experience that includes sensory and
emotional/motivational responses. Accordingly, pain serves as a powerful teaching signal …

The molecular/genetic era has seen the discovery of a staggering number of molecules
implicated in pain mechanisms [18],[35],[61],[69],[96],[133],[150],[202],[224]. This has …

Pain is necessary for survival, but persistent pain can result in anxiety, depression and a
reduction in the quality of life. The discriminative and affective qualities of pain are both …

Abstract Information about bodily events is conveyed by primary sensory fibres to higher
brain centres through neurons in the dorsal column nuclei (DCN) and spinal dorsal horn …

In mice, spared nerve injury replicates symptoms of human neuropathic pain and induces
upregulation of many genes in somatosensory neurons. Here we used single cell …

Itch, in particular chronic forms, has been widely recognized as an important clinical
problem, but much less is known about the mechanisms of itch in comparison with other …

The anterolateral pathway consists of ascending spinal tracts that convey pain, temperature
and touch information from the spinal cord to the brain,,–. Projection neurons of the …

Persistent mechanical hypersensitivity that occurs in the setting of injury or disease remains
a major clinical problem largely because the underlying neural circuitry is still not known …

Humans and mice detect pain, itch, temperature, pressure, stretch and limb position via
signaling from peripheral sensory neurons. These neurons are divided into three functional …

Response to danger needs to be rapid and appropriate. In humans, nocifensive behaviors
often precede conscious pain perception. Much is known about local spinal cord circuits for …