Epigenetic mechanisms of gene regulation are defined as reversible but heritable events.
They control the accessibility of DNA to transcription factors and RNA polymerases, thereby …

Epigenetic changes are reversible but heritable events. They control the accessibility of DNA
to elements of the transcriptional complex, including transcription factors and RNA …

The pathogenesis of autoimmune diseases involves a breach of immune tolerance, which
can occur through a variety of mechanisms. As is the case with many diseases, it is widely …

More than 100 types of autoimmune disorders have been identified so far, and most of them
are usually chronic in nature. Multiple agents are known to have a role in causing …

Recent successes of therapeutic intervention in chronic inflammatory diseases using
epigenetic modifiers such as histone deacetylase inhibitors and inhibitors of DNA …

During recent years, numerous studies have shown that epigenetics, heritable changes that
do not involve alterations in the DNA sequence, play an important role in the development …

Systemic inflammatory rheumatic diseases are considered as autoimmune diseases,
meaning that the balance between recognition of pathogens and avoidance of self‐attack is …

Recent genome-wide association studies have documented a number of genetic variants to
explain mechanisms underlying autoimmune diseases. However, the precise etiology of …

Immune-mediated diseases are clinically heterogeneous but they share genetic and
pathogenic mechanisms. These diseases may develop from the interplay of genetic factors …

There has been an explosion of knowledge in the epigenetics field in the past 20 years. The
first epigenetic therapies have arrived in the clinic for cancer treatments. In contrast, much of …