Accumulation of unfolded proteins in the endoplasmic reticulum (ER) activates the unfolded
protein response (UPR). In mammalian cells, UPR signals generated by several ER …

The function of the endoplasmic reticulum (ER) can be impaired by changes to the extra-and
intracellular environment, such as disruption of calcium homeostasis, expression of mutated …

An accumulation of misfolded proteins in the endoplasmic reticulum (ER) triggers the
unfolded protein response (UPR) mediated via the activation of three transmembrane …

The endoplasmic reticulum (ER) is a multifunctional organelle that constitutes the entry into
the secretory pathway. The ER contributes to the maintenance of cellular calcium …

The unfolded protein response (UPR) is a conserved adaptive response utilized by cells to
cope with endoplasmic reticulum (ER) stress. In addition to the UPR, cells also trigger other …

Stress induced by accumulation of unfolded proteins at the endoplasmic reticulum (ER) is a
classic feature of secretory cells and is observed in many tissues in human diseases …

Endoplasmic reticulum (ER) stress activates an adaptive unfolded protein response (UPR)
that facilitates cellular repair, however, under prolonged ER stress, the UPR can ultimately …

Increasing evidence indicates that endoplasmic reticulum (ER) stress activates the adaptive
unfolded protein response (UPR), but that beyond a certain degree of ER damage, this …

Within the cell, several mechanisms exist to maintain homeostasis of the endoplasmic
reticulum (ER). One of the primary mechanisms is the unfolded protein response (UPR). In …

In response to stress, the endoplasmic reticulum (ER) signaling machinery triggers the
inhibition of protein synthesis and up-regulation of genes whose products are involved in …