With an ageing world population and over 20% of adults in Europe affected by bone
disorders, there is urgency in developing advanced strategies and tissue regenerative …

The cellular response to surfaces is mediated, among other factors, by the extracellular
matrix (ECM). However, little is known about the ECM proteome during mineralization. Our …

Biomineralization is a complex process that requires a biological synchronization of cells.
These cells orchestrate the production of an extracellular matrix composed of collagen …

The ultrastructure, as visualized by transmission electron microscopy, of cells obtained from
human bone explants and subsequently cultured is described along with the electron …

Bone is a hierarchically structured composite material which, in addition to its obvious
biological value, has been well studied by the materials engineering community because of …

This work describes the development of a three-dimensional (3D) model of osteogenesis
using mouse preosteoblastic MC3T3-E1 cells and a soft synthetic matrix made out of self …

Biomineralisation of collagen involves functional motifs incorporated in extracellular matrix
protein molecules to accomplish the objectives of stabilising amorphous calcium phosphate …

Bone-forming cells fabricate a highly ordered collagen matrix (osteoid) which subsequently
mineralizes. A variety of cell culture systems exist for osteogenic cells, yet none of these is …

Objective To prepare biomimetic bone material by reconstructing type Ⅰ collagen combined
with polyaspartic acid. Methods By acid hydrolysis, rat tail type Ⅰ collagen was decomposed …