Cancer therapy drugs, such as diamminedichloroplatinum (cisplatin), mitomycin C,
etoposide and a number of other compounds, as well as energy-rich radiation, are known to …

We have investigated the effect of chemotherapeutic and DNA damaging agents on binding
of the tumor suppressor phosphoprotein p53 to its consensus DNA sequence. Activation of …

T HE CONCEPT THAT p53 is a tumor-suppressor gene was developed through two major
facets. One facet entailed the laboratory experiments in which it was realized that wild-type …

From the $ Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health,
Bethesda, Maryland 20892, the $ Biology Department, Brookhaven National Laboratory …

In human tumourigenesis the tumour suppressor gene most commonly affected by mutation,
inactivation or allele loss is p53. Loss of p53 function is associated both with failure to …

We examined synthesis of the cellular phosphoprotein p53 in fresh bone marrow or
peripheral blood cells from normal donors and from patients with leukemia, preleukemia, or …

While the centrality of aberrant cell proliferation in cancer was widely acknowledged long
ago, it is only recently that the control of cell death has been recognized as an important …

Mutations of the p53 tumor suppressor gene are rarely found in neuroblastoma. Though
typically a nuclear protein, a number of tumor cell types have recently been reported to …

A wild-type p53 gene under control of the metallothionein MT-1 promoter was stably
transfected into human colon tumor-derived cell line EB. Repeated inductions of the …

Publisher Summary The chapter focuses on p53—that is, a cell cycle regulator activated by
deoxyribonucleic acid (DNA) damage. Mutations in the p53 tumor-suppressor gene occur at …