Monoclonal antibody directed against the transformation-related protein p53 was
microinjected manually into the nuclei of quiescent Swiss 3T3 mouse cells. The cells were …

The expression of the tumour suppressor gene p53 was analysed in 11 human breast
cancer cell lines by immunohistochemistry, immunoprecipitation and cDNA sequencing. We …

In the present study, we report the characterization of the p53 tumor suppressor pathway in
the 60 cell lines of the National Cancer Institute (NCI) anticancer drug screen, as well as …

The tumor-suppressor protein p53 has been called the “Cellular Gatekeeper” and a
“Guardian of the Genome” for its well-documented activities in causing cell cycle arrest and …

Thep53 tumour suppressor gene acts to prevent the development of cancer (Donehower et
al., 1992). It does so as “the guardian of the genome”(Lane, 1992) by blocking the division of …

Twenty-seven cases of inflammatory breast cancer were screened for the presence of the
p53 protein by immunocytochemical methods using a monoclonal antibody directed against …

Wild-type p53 has recently been shown to repress transcription from several cellular and
viral promoters. Since p53 mutations are the most frequently reported genetic defects in …

We investigated the immunocytochemical staining and immunoblotting characteristics of 33
different p53 mutant proteins identified in lung cancer cell lines (18 small-cell lung cancer …

Suppression of tumor cell growth by p53 results from the activation of both apoptosis and
cell cycle arrest, functions which have been shown to be separable activities of p53. We …

Accumulation of the p53 protein was analysed in 212 human malignant lesions.
Immunohistochemical staining with new polyclonal (CM-1) and monoclonal antibodies (BP …