Cytotoxicity and genotoxicity of anticancer drugs to the normal cells are major problems in
cancer therapy and endanger the risk of inducing secondary malignancy. Current regimen …

Cancer is one of the leading causes of death. Globally a huge number of deaths and new
incidences are reported annually. Heterocyclic compounds have been proved to be very …

Synthesis of twenty new curcumin inspired 2-chloro/phenoxy quinoline derivatives is
outlined in this study. The obtained new chemical entities were screened in vitro for their …

Abstract Novel 6, 7-methylenedioxy-4-substituted phenylquinolin-2 (1H)-one derivatives 12a–
n were designed and prepared through an intramolecular cyclization reaction and evaluated …

Quinoline derivatives are considered broad-spectrum pharmacological compounds that
exhibit a wide range of biological activities. Integration of quinoline moiety can improve its …

Due to the pharmacological activities of quinazoline and quinazolinone scaffolds, it has
aroused great interest in medicinal chemists for the development of new drugs or drug …

Two series of quinoline–thiazole and quinoline–thiazolidinone hybrids were designed,
synthesized, and evaluated for their in vitro antitumor activity on MCF‐7 breast cancer cell …

The chemistry of quinolones, representing one of the major classes of nitrogen-containing
heterocyclics, has received more attention and considered one of the promising …

Hydroxyquinoline (8-HQ) is a significant heterocyclic scaffold in organic and analytical
chemistry because of the properties of chromophore and is used to detect various metal ions …

Aims: To explore more active fluoroquinolone anticancer candidates. Background: Cancer
which can affect almost any part of the body, is most striking and deadliest disease. It is …