Receptors and Channels Associated with Alcohol Use: Contributions from Drosophila

KM Scaplen, E Petruccelli - Neuroscience Insights, 2021 - journals.sagepub.com
Alcohol Use Disorder (AUD) is a debilitating disorder that manifests as problematic patterns
of alcohol use. At the core of AUD's behavioral manifestations are the profound structural …

Insights from intoxicated Drosophila

E Petruccelli, KR Kaun - Alcohol, 2019 - Elsevier
Our understanding of alcohol use disorder (AUD), particularly alcohol's effects on the
nervous system, has unquestionably benefited from the use of model systems such as …

The Neurotransmitters Involved in Drosophila Alcohol-Induced Behaviors

MM Chvilicek, I Titos, A Rothenfluh - Frontiers in behavioral …, 2020 - frontiersin.org
Alcohol is a widely used and abused substance with numerous negative consequences for
human health and safety. Historically, alcohol's widespread, non-specific neurobiological …

The genetics of alcohol responses of invertebrate model systems

A Rothenfluh, BR Troutwine… - Neurobiology of …, 2014 - utsouthwestern.elsevierpure.com
Alcohol use disorders and alcoholism are prevalent conditions that come at a high cost for
individuals and for society at large. About half the factors contributing to the development of …

Unraveling the mechanisms of behaviors associated with AUDs using flies and worms

H Scholz - Alcoholism: Clinical and Experimental Research, 2019 - Wiley Online Library
Alcohol use disorders (AUDs) are very common worldwide and negatively affect both
individuals and societies. To understand how normal behavior turns into uncontrollable use …

Drosophila and Caenorhabditis elegans as Discovery Platforms for Genes Involved in Human Alcohol Use Disorder

M Grotewiel, JC Bettinger - Alcoholism: Clinical and …, 2015 - Wiley Online Library
Background Despite the profound clinical significance and strong heritability of alcohol use
disorder (AUD), we do not yet have a comprehensive understanding of the naturally …

Synaptic Mechanisms of Ethanol Tolerance and Neuroplasticity: Insights from Invertebrate Models

A Bhandari, A Seguin, A Rothenfluh - International Journal of Molecular …, 2024 - mdpi.com
Alcohol tolerance is a neuroadaptive response that leads to a reduction in the effects of
alcohol caused by previous exposure. Tolerance plays a critical role in the development of …

Studying alcohol use disorder using Drosophila melanogaster in the era of 'Big Data'

GL Engel, K Taber, E Vinton, AJ Crocker - Behavioral and Brain Functions, 2019 - Springer
Our understanding of the networks of genes and protein functions involved in Alcohol Use
Disorder (AUD) remains incomplete, as do the mechanisms by which these networks lead to …

Addiction-like behavior in Drosophila

AV Devineni, U Heberlein - Communicative & integrative biology, 2010 - Taylor & Francis
Alcohol abuse is a pervasive problem known to be influenced by genetic factors, yet our
understanding of the mechanisms underlying alcohol addiction is far from complete …

Long-lasting, experience-dependent alcohol preference in Drosophila

SA Ojelade, PS Penninti, RJ Dove, MJ Nye… - Addiction …, 2013 - pmc.ncbi.nlm.nih.gov
To understand the molecular and neural mechanisms underlying alcohol addiction, many
models ranging from vertebrates to invertebrates have been developed. In Drosophila …