Background: Antimicrobial resistance is a serious public-health problem throughout the
world. Escherichia coli, the most common Gram-negative microorganism, has developed …

Abstract Objectives In November 2015, a plasmid-mediated colistin resistance, MCR-1, was
described in animals, food and humans in China, and it was considered as a potential …

Colistin is considered to be an antimicrobial of last-resort for the treatment of multidrug-
resistant Gram-negative bacterial infections. The recent global dissemination of mobilized …

Since the first description of a plasmid-mediated colistin resistance gene (mcr-1) in
November 2015 multiple reports of mcr-1 positive isolates indicate a worldwide spread of …

Colistin is an old antimicrobial that has been revitalized as last-resort treatment against
multidrug-resistant (MDR) gram-negative bacterial infections. However, colistin has been …

Colistin resistance by mobilisable mcr genes has been described in bacteria of food-animal
origin worldwide, which has raised public health concerns about its potential foodborne …

Objectives The continuing rise in infections caused by multidrug-resistant (MDR) bacteria is
one of the most serious public-health issues in society today. Colistin is a last-resort …

The emergence of the plasmid-mediated colistin resistance gene mcr-1 is threatening the
last-line role of colistin in human medicine. With mcr-1-positive Escherichia coli (E. coli) …

Objectives The emergence of colistin-resistant Enterobacteriaceae from human and animal
sources is one of the major public health concerns as colistin is the last-resort antibiotic for …

We screened mcr-1 and mcr-2 genes in 9,306 Escherichia coli strains isolated from healthy
animals in the Japanese Veterinary Antimicrobial Resistance Monitoring (JVARM) system …