Dendritic cells (DCs) are potent antigen-presenting cells critical in regulating the adaptive
immune response. The role of DCs is dichotomous; they may both present antigens and the …

Deciphering the origins of chronic inflammatory and autoimmune diseases remains elusive
with reliance on therapies aimed at halting inflammation in its tracks. In recent years, an …

Dying cells have an important role in the initiation of CD8+ T cell-mediated immunity. The
cross-presentation of antigens derived from dying cells enables dendritic cells to present …

Sepsis is a deadly inflammatory syndrome caused by an exaggerated immune response to
infection. Much has been focused on host response to pathogens mediated through the …

The response to exogenous pathogens leads to activation of innate immunity through the
release of pathogen-associated molecular patterns (PAMPs) and their binding to pattern …

Tissue damage triggers a rapid and robust inflammatory response in order to clear and
repair a wound. Remarkably, many of the cell biology features that underlie the ability of …

Innate immune receptors, well known mediators of response to non-self-molecules and
inflammation, also act as mediators of immunity triggered by 'damage-associated molecular …

Cellular components released into the external milieu as a result of cell death and sensed
by the body are generally termed damage-associated molecular patterns (DAMPs) …

Multicellular animals detect pathogens via a set of receptors that recognize pathogen-
associated molecular patterns (PAMPs). However, pathogens are not the only causative …

The immunogenicity of malignant cells has recently been acknowledged as a critical
determinant of efficacy in cancer therapy. Thus, besides developing direct …