Neutrophils are key innate immune effector cells that are rapidly recruited to sites of infection
and inflammation to provide early defence against invading microorganisms. This function is …

Acute inflammation is traditionally characterized by polymorphonuclear leukocytes (PMN)
influx followed by phagocytosing macrophage (Mφs) that clear injurious stimuli leading to …

The acute inflammatory response is a double-edged sword. On the one hand, it plays a key
role in initial host defense, particularly against many infections. On the other hand, its aim is …

Sterile inflammation can be initiated by innate immune recognition of markers of tissue injury
termed damage-associated molecular patterns (DAMPs). DAMP recognition by dendritic …

Liberation of damage-associated molecular patterns (DAMPs) following tissue injury and
necrotic cell death leads to the induction of sterile inflammation. A hallmark of acute …

This opinion article discusses the increasing attention paid to the role of activating damage-
associated molecular patterns (DAMPs) in initiation of inflammatory diseases and …

Severe trauma is accompanied by a profound activation of the immune system. Patients with
polytrauma develop systemic inflammatory response syndrome (SIRS) and often sepsis …

There are well-established links between acute inflammation and successful tissue repair
across evolution. Innate immune reactions contribute significantly to pathogen clearance …

The response to pathogens and damage in plants and animals involves a series of carefully
orchestrated, highly evolved, molecular mechanisms resulting in pathogen resistance and …

Damage to any tissue triggers a cascade of events that leads to rapid repair of the wound–if
the tissue is skin, then repair involves re-epithelialization, formation of granulation tissue and …