The role of polymorphonuclear neutrophils (PMNs) in biology is often recognized during
pathogenesis associated with PMN hyper-or hypo-functionality in various disease states …

Acute inflammation normally resolves by mechanisms that have remained somewhat
elusive. Emerging evidence now suggests that an active, coordinated program of resolution …

Sepsis was first described by the ancient Greek physicians over 2000 years ago. The
pathophysiology of the disease, however, is still not fully understood and hence the mortality …

Significance: This review article provides an overview of the critical roles of the innate
immune system to wound healing. It explores aspects of dysregulation of individual innate …

The innate immune system is the first line of defense against invading pathogens or sterile
injuries. Pattern recognition receptors (PRR) sense molecules released from inflamed or …

Damage-associated molecular patterns (DAMPs) are released in response to cell death and
stress, and are potent triggers of sterile inflammation. Recent evidence suggests that DAMPs …

It is now well accepted that the innate immune system recognizes both damage (or danger)-
and pathogen-associated molecular patterns (DAMP and PAMP, respectively) through …

Resolution of inflammation is a coordinated and active process aimed at restoration of tissue
integrity and function. This review integrates the key molecular and cellular mechanisms of …

Immune-driven resistance mechanisms are the prevailing host defense strategy against
infection. By contrast, disease tolerance mechanisms limit disease severity by preventing …

Initially after injury, the innate/proinflammatory and some aspects of the acquired immune
response are up-regulated to maintain a defense against foreign pathogens, clear tissue …