The concept that chemokines, cytokines and pro-inflammatory mediators act in a co-
ordinated fashion to drive the initiation of the inflammatory reaction is well understood. The …

Wounding of tissue barriers, such as epithelia, disrupts homeostasis and allows infection.
Within minutes, animals detect injury and respond to it by recruitment of phagocytes and …

Cells of the innate immune system build immunological memory via epigenetic
reprogramming after stimulations with microbial ligands. This functional readjustment allows …

Most tissues harbor resident mononuclear phagocytes, that is, dendritic cells and
macrophages. A classification that sufficiently covers their phenotypic heterogeneity and …

Inflammation is a response to infections or tissue injuries. Inflammation was once defined by
clinical signs, later by the presence of leukocytes, and nowadays by expression of …

The elaboration of an effective immune response against pathogenic microbes such as
viruses, intracellular bacteria or protozoan parasites relies on the recognition of microbial …

Wound healing is a complex physiological process comprised of discrete but inter-related
and overlapping stages, requiring exact timing and regulation to successfully progress, yet …

Acute inflammation is a localized and self-limited innate host-defense mechanism against
invading pathogens and tissue injury. Neutrophils, the most abundant immune cells in …

Members of the Federation of Clinical Immunology Societies are invited to attend an exciting
meeting on damage-associated molecular pattern molecules [DAMPs] in acute and chronic …

Trauma is one of the leading causes of death and disability in the world. Multiple trauma or
isolated traumatic brain injury are both indicative of human tissue damage. In the early …