The fundamental role played by neutrophils for an efficient, acute inflammatory response
has long been appreciated, with the underlying molecular and cellular mechanisms largely …

As one of the first defenders of innate immune response, neutrophils make a rapid and
robust response against infection or harmful agents. While traditionally regarded as suicidal …

Acute inflammation is traditionally described as the influx of polymorphonuclear leukocytes
(PMNs) followed by monocyte-derived macrophages, leading to resolution. This is a classic …

Neutralizing injurious stimuli, proinflammatory mediator catabolism, and polymorphonuclear
leukocyte (PMN) clearance are determinants of inflammatory resolution. To this, we recently …

The innate immune system uses a distinct set of germline-encoded pattern recognition
receptors (PRRs) to initiate downstream inflammatory cascades. This recognition system is …

Autoimmune disease can develop as a result of a breakdown in immunological tolerance,
leading to the activation of self-reactive T cells. There is an established link between …

Macrophages are essential for the efficient healing of numerous tissues, and they contribute
to impaired healing and fibrosis. Tissue repair proceeds through overlapping phases of …

Infections, cardiovascular disease, and cancer are major causes of disease and death
worldwide. Neutrophils are inescapably associated with each of these health concerns, by …

Inflammation is triggered when innate immune cells detect infection or tissue injury.
Surveillance mechanisms involve pattern recognition receptors (PRRs) on the cell surface …

Fungal infections and diseases predominantly affect patients with deregulated immunity.
Compelling experimental and clinical evidence indicate that severe fungal diseases belong …