Dendritic cells (DCs) initiate and control immune responses, participate in the maintenance
of immunological tolerance and are pivotal players in the pathogenesis of autoimmunity. In …

The innate immune system uses a distinct set of germline-encoded pattern recognition
receptors (PRRs) to initiate downstream inflammatory cascades. This recognition system is …

Inflammation is triggered when innate immune cells detect infection or tissue injury.
Surveillance mechanisms involve pattern recognition receptors (PRRs) on the cell surface …

Autoimmune disease can develop as a result of a breakdown in immunological tolerance,
leading to the activation of self-reactive T cells. There is an established link between …

Infections, cardiovascular disease, and cancer are major causes of disease and death
worldwide. Neutrophils are inescapably associated with each of these health concerns, by …

Neutrophils have long been known to participate in acute inflammation, but a role in chronic
inflammatory and autoimmune diseases is now emerging. These cells are key players in the …

The goal of treating chronic inflammatory diseases must be to inhibit persistent inflammation
and restore tissue function. To achieve this we need to improve our understanding of the …

Inflammation is classically recognized as an essential step for the control of microbial
invasion or tissue injury as well as for the maintenance of tissue homeostasis under a variety …

Autoinflammation as a distinct disease category was first reported in 1999 as a group of
monogenic disorders characterized by recurrent episodes of systemic and organ-specific …

The autoinflammatory diseases are characterized by seemingly unprovoked episodes of
inflammation, without high-titer autoantibodies or antigen-specific T cells. The concept was …