Abstract The phosphoinositide 3-kinase (PI3K) pathway is an intracellular signaling pathway
that has regulatory roles in cell survival, proliferation, and differentiation, and a critical role in …

Protein kinases are targets for treatment of a number of diseases. This review focuses on
kinase inhibitors that are in the clinic or in clinical trials and for which structural information is …

Small-molecule kinase inhibitors are invaluable targeted therapeutics for the treatment of
various human diseases, especially cancers. While the majority of approved and developed …

Abstract mTOR (mammalian Target of Rapamycin) is the hub of the phosphoinositide 3-
Kinase (PI3-K)→ Akt→ mTOR pathway, which is one of the most commonly mutated …

Because dysregulation of protein kinases owing to mutations or overexpression plays
causal roles in human diseases, this family of enzymes has become one of the most …

Landmark clinical studies of new drugs developed to target specific forms of cancer were
reported in 2001. Herceptin, a monoclonal antibody against the Her2/neu receptor tyrosine …

Protein kinases have emerged as one of the most frequently targeted families of proteins in
drug discovery. While the development of small-molecule inhibitors that have the potency …

The human genome comprises more than 500 protein kinases including serine/threonine,
tyrosine and dual specificity kinases. 1, 2 Because of the important physiological and …

High-throughput and virtual screening are widely used to discover novel leads for drug
design. On examination, many screening hits appear non-drug-like: they act …

Over the past decade, therapeutics that target subsets of the 518 human protein kinases
have played a vital role in the fight against cancer. Protein kinases are typically targeted at …