Solid tumours contain regions at very low oxygen concentrations (hypoxia), often
surrounding areas of necrosis. The cells in these hypoxic regions are resistant to both …

There is overwhelming evidence that solid human tumours grow within a unique micro-
environment. This environment is characterised by an abnormal vasculature, which leads to …

Tumor hypoxia has long been recognized as a critical issue in oncology. Resistance of
hypoxic areas has been shown to affect treatment outcome after radiation, chemotherapy …

Hypoxia is a feature of most tumours, albeit with variable incidence and severity within a
given patient population. It is a negative prognostic and predictive factor owing to its multiple …

Human solid tumors are invariably less well‐oxygenated than the normal tissues from which
they arose. This so‐called tumor hypoxia leads to resistance to radiotherapy and anticancer …

Cells undergo a variety of biological responses when placed in hypoxic conditions,
including activation of signalling pathways that regulate proliferation, angiogenesis and …

The presence of a microenvironment within most tumours containing regions of low oxygen
tension or hypoxia has profound biological and therapeutic implications. Tumour hypoxia is …

Hypoxia exerts a profound impact on diverse aspects of cancer biology. Increasing evidence
has revealed novel functions of hypoxia in cancer cell epigenomics, epitranscriptomics …

Tumor hypoxia or a reduction of the tissue oxygen tension is a key microenvironmental
factor for tumor progression and treatment resistance in solid tumors. Because hypoxic …

Hypoxia is a common feature of malignant tumors. There is an interactive connection
between hypoxia and chemoresistance, radioresistance, invasiveness, and angiogenesis …