LT was one of the first lymphokines to be described and has been one of the most difficult to
fit into a conceptual framework. Now, 20 years after its discovery, its structure, genetic …

The murine lymphotoxin (LT) gene has been cloned and used to identify cDNA clones in a
library prepared from activated murine T cell mRNA. A recombinant murine genomic library …

Lymphotoxin (LT) is a cytokine related to TNF, found in human systems in both secreted and
membrane bound forms. The well characterized secreted form is a trimer of a single protein …

We characterized the membrane-associated form of lymphotoxin (surface LT) on the
activated II-23. D7 T cell hybridoma. Antibodies to rLT precipitated both surface LT and a …

The lymphokine tumor necrosis factor (TNF) has a well-defined role as an inducer of
inflammatory responses; however, the function of the structurally related molecule …

The tumor necrosis factor (TNF)-related cytokines have emerged over the past 2 years as a
large family of pleiotropic mediators of host defense and immune regulation. Members of this …

The lymphotoxin-alpha beta complex (LT alpha beta) is found on the surface of activated
lymphocytes and binds to a specific receptor called the LT beta receptor (LT beta R). In the …

A human T cell hybridoma, II-23. D7, was induced with phorbol ester to express a surface
form of lymphotoxin (LT, TNF-beta) and an associated 33-kDa glycoprotein. The LT epitopes …

The expression of membrane-associated forms of lymphotoxin (LT) and TNF were examined
on cell lines of T, B, and myeloid origin, IL-2 dependent T cell clones, and peripheral blood …

Lymphotoxin (LT) is a cytokine that orchestrates lymphoid neogenesis and formation of
germinal center reactions. LT exists as a membrane heterotrimer of α and β subunits and is …