Spermatogenesis is composed of three distinctive phases, which include self-renewal of
spermatogonia via mitosis, spermatocytes undergoing meiosis I/II and post-meiotic …

Along with many of the genome-wide transitions in chromatin composition throughout
spermatogenesis, epigenetic modifications on histone tails and DNA are continuously …

In mammals, male gametes are produced inside the testis by spermatogenesis, which has
three phases: mitotic proliferation of spermatogonia, meiosis of spermatocytes, and haploid …

Mammalian spermatogenesis contains three continuous and organized processes, by which
spermatogonia undergo mitosis and differentiate to spermatocytes, follow on meiosis to form …

BACKGROUND Achieving the correct spatial and temporal expression of germ-cell-specific
genes is fundamental to the production of viable healthy spermatozoa. Notably, post …

Infertility is a significant problem for human reproduction, with males and females equally
affected. However, the molecular mechanisms underlying male infertility remain unclear …

Infertility is an often devastating diagnosis encountered by around one in six couples who
are trying to conceive. Moving away from the long-held belief that infertility is primarily a …

Human spermatogenesis includes three main stages, namely, the mitosis of spermatogonia,
meiosis of spermatocytes, and spermiogenesis of spermatids, which are precisely regulated …

Sperm undergo some of the most extensive chromatin modifications seen in mammalian
biology. During male germline development, paternal DNA methylation marks are erased …

Infertility is rarely life threatening, however, it poses a serious global health issue posing far-
reaching socio-economic impacts affecting 12–15% of couples worldwide where male factor …