Mice, deficient for vascular endothelial growth factor VEGF-A in pancreatic islets, have
reduced insulin gene expression levels and an impaired glucose tolerance. Here, we …

Previously, we found that the islet of pancreas stained with a antibody against the vascular
permeability factor (VPF; also known as vascular endothelial growth factor, VEGF) protein …

We have previously shown that the tyrosine kinase receptor Flk-1 and its ligand, vascular
endothelial growth factor (VEGF), may play a role in the development of fetal rat islet-like …

Aims/hypothesis Vascular endothelial growth factor (VEGF) has been recognised by loss-of-
function experiments as a pleiotropic factor with importance in embryonic pancreas …

Endocrine and exocrine pancreatic morphogenesis is known to occur from ductal
epithelium, but the factors that regulate this process are unknown. Vascular endothelial …

Aims/hypothesis Endothelial cells are considered to be essential for normal pancreatic beta
cell function. However, there have been no reports showing their importance for beta cell …

The mechanisms underlying zebrafish pancreatic islet vascularization have not been well
characterized. We sought to determine the angiogenic factors responsible for islet …

Owing to strong interactions between pancreatic islets and the surrounding capillary
network, we hypothesized that high glucose concentrations might affect key angiogenesis …

Aims/hypothesis Vascular endothelial growth factor (VEGF) is essential for proper pancreatic
development, islet vascularisation and insulin secretion. In the adult pancreas, VEGF is …

It is generally accepted that vascularization and oxygenation of pancreatic islets are
essential for the maintenance of an optimal β-cell mass and function and that signaling by …