Successful islet transplantation depends on the infusion of sufficiently large quantities of
islets, of which only∼ 30% become stably engrafted. Rapid and adequate revascularization …

Endothelial cells (ECs) are essential for pancreas differentiation, endocrine specification,
and endocrine function. They are also involved in the physiopathology of type 1 and type 2 …

Endothelial cells represent one of the most abundant and widely found cell types in the
mammalian embryo. These cells arise in close proximity with and often as an integral part of …

Pancreatic islets adapt to insulin resistance through a complex set of changes, including β-
cell hyperplasia and hypertrophy. To determine if islet vascularization changes in response …

Owing to strong interactions between pancreatic islets and the surrounding capillary
network, we hypothesized that high glucose concentrations might affect key angiogenesis …

Microvascular development is determined by the interplay between tissue cells and
microvascular endothelial cells. Because the pancreatic islet is an organ composed mainly …

Insulin-producing β-cells constitute the majority of the cells in the pancreatic islets.
Dysfunction of these cells is a key factor in the loss of glucose regulation that characterizes …

Vascular endothelial growth factor (VEGF) is an endothelial cell-specific mitogen with potent
angiogenic and vascular permeability-inducing properties, both of which may be important …

Pancreatic islet transplantation is an emerging therapy for type 1 diabetes. To survive and
function, transplanted islets must revascularize because islet isolation severs arterial and …

Aims/hypothesis The proximity of endothelial cells and beta cells in islets by necessity
means that they are exposed to each other's products. Whereas islet endothelial cells …