The growth of both tumors and nonneoplastic tissues may be influenced by signals from the
vascular endothelium. In the present investigation we show that purified proliferating …

β-Cells respond to peripheral insulin resistance by first increasing circulating insulin during
diabetes. Islet remodeling supports this compensation, but its drivers remain poorly …

Maintenance of glucose homeostasis depends on adequate amount and precise pattern of
insulin secretion, which is determined by both β-cell secretory processes and well …

Type 2 diabetes mellitus (T2DM) affects millions of people and is linked with obesity and
lipid accumulation in peripheral tissues. Increased lipid handling and lipotoxicity in insulin …

Islet vascularization is essential for intact islet function and glucose homeostasis. We have
previously shown that primary cilia directly regulate insulin secretion. However, it remains …

Endocrine pancreatic β cells require endothelial signals for their differentiation and function.
However, the molecular basis for such signals remains unknown. Here, we show that β cells …

Gene expression profiling of islets from pre-diabetic male Zucker diabetic fatty (ZDF) rats
showed increased expression of hypoxia-related genes, prompting investigation of the …

Pancreatic islets are clusters of endocrine cells that secrete different hormones to regulate
blood glucose levels. Efficient hormone secretion requires a close interaction of endocrine …

A better understanding of processes controlling the development and function of pancreatic
islets is critical for diabetes prevention and treatment. Here, we reveal a previously …

The pancreatic islets are one of the most vascularized organs of the body. This likely reflects
the requirements of the organ for a rich supply of nutrients and oxygen to the tissue, as well …