The pancreatic islet is highly vascularised, with an extensive capillary network. In addition to
providing nutrients and oxygen to islet endocrine cells and transporting hormones to the …

Islet transplantation has been hampered by loss of function due to poor revascularization.
We hypothesize that co-transplantation of islets with human embryonic stem cell-derived …

The intra-islet microvasculature is a critical interface between the blood and islet endocrine
cells governing a number of cellular and pathophysiological processes associated with the …

Blood vessels form a highly branched, interconnected, and largely stereotyped network of
tubes that sustains every organ and tissue in vertebrates. How vessels come to take on their …

The formation of new microvasculature by capillary sprouting at the site of islet
transplantation is crucial for the long-term survival and function of the graft. Vascular …

Blood vessels course through organs, providing them with essential nutrient and gaseous
exchange. However, the vasculature has also been shown to provide non-nutritional signals …

OBJECTIVE—Chronic pancreatitis, characterized by pancreatic exocrine tissue destruction
with initial maintenance of islets, eventually leads to insulin-dependent diabetes in most …

Aims/hypothesis Rapamycin, part of the immunosuppressive regimen of the Edmonton
protocol, has been shown to inhibit vascular endothelial growth factor (VEGF) production …

The microvasculature is a key interface between blood and tissues and participates in
numerous pathophysiological processes. The heterogeneity of microvascular endothelial …

Although endothelial cells have been shown to affect mouse pancreatic development, their
precise function in human development remains unclear. Using a coculture system …