Abstract Background/Aims: An important reason for the large amount of islets required for
successful islet transplantation is likely to be inadequate engraftment of the transplanted …

Objective The maintenance and expansion of β-cell mass rely on their proliferation, which
reaches its peak in the neonatal stage. β-cell proliferation was found to rely on cells of the …

Embryonic stem cells (ESC) have two main characteristics: they can be indefinitely
propagated in vitro in an undifferentiated state and they are pluripotent, thus having the …

The aim of the present study was to investigate possible changes in the islet
microvasculature during the period of pronounced β‐cell growth seen perinatally in rats. We …

Islet neogenesis, or the differentiation of islet cells from precursor cells, is seen in vitro and in
vivo both embryonically and after birth. However, little is known about the differentiation …

Aims The transcriptome of different dissociated pancreatic islet cells has been described in
enzymatically isolated islets in both health and disease. However, the isolation, culturing …

Background The family of vascular endothelial growth factors (VEGF) contains key
regulators of blood and lymph vessel development, including VEGF-A,-B,-C,-D, and …

New blood vessel formation in transplanted islets occurs within 7–14 days post‐
transplantation through both the expansion of donor islet endothelium and ingrowth of blood …

Pancreatic acini and islets are believed to differentiate from common ductal precursors
through a process requiring various growth factors. Epidermal growth factor receptor (EGF …

Aims/hypothesis The initial avascular period following islet transplantation seriously
compromises graft function and survival. Enhancing graft revascularisation to improve …