We used cre/loxP-based genetic lineage tracing analysis to test a previously proposed
hypothesis that in vitro cultured adult pancreatic β-cells undergo epithelial-mesenchymal …

The islets of Langerhans is the endocrine function region of pancreas, which exist in five cell
types. The majority of endocrine cells are insulin-secreting β cells, mixed up with glucagon …

OBJECTIVE β-Cell and islet endothelial cell destruction occurs during the progression of
type 1 diabetes, but, paradoxically, β-cell proliferation is increased during this period …

The formation of a new microvasculature is essential for the long-term survival and function
of the islet graft. In this study we examined endothelium of isolated pancreatic islets by …

Transplantation of pancreatic islets reconstitutes glucose homeostasis in diabetes mellitus.
Before transplantation, islets are disrupted from the surrounding blood vessels by the …

Lack of rapid revascularization and inflammatory attacks at the site of transplantation
contribute to impaired islet engraftment and suboptimal metabolic control after clinical islet …

All pancreatic cell populations arise from the standard gut endoderm layer in developing
embryos, requiring a regulatory gene network to originate and maintain endocrine lineages …

As one of the key nutrient sensors, insulin signaling plays an important role in integrating
environmental energy cues with organism growth. In adult organisms, relative insufficiency …

The extracellular matrix (ECM) critically affects β cell functions via integrin activation. But
whether these ECM actions drive the spatial organization of β cells, as they do in epithelial …

The targeted disruption of the two nonallelic insulin genes in mouse was reported previously
to result in intrauterine growth retardation, severe diabetes immediately after suckling, and …